연구성과 홍보

Biochim Biophys Acta Rev Cancer. 2025 Feb;1880(1):189251.

Title : Exploring the gut microbiome: A potential biomarker for cancer diagnosis, prognosis, and therapy

Authors : Eui-Jeong Han1, Ji-Seon Ahn1, Yu-Jin Choi1, Da-Hye Kim1, Jong-Soon Choi2, Hea-Jong Chung3*

Affiliations :

1Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.

2Research Center for Materials Analysis, Korea Basic Science Institute, Daejeon 34133, Republic of Korea; College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.

3Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.

DOI: 10.1016/j.bbcan.2024.189251

Abstract :

The gut microbiome, a complex community of trillions of microorganisms in the intestines, is crucial in maintaining human health. Recent advancements in microbiome research have unveiled a compelling link between the gut microbiome and cancer development and progression. Alterations in the composition and function of the gut microbiome, known as dysbiosis, have been implicated in various types of cancer, including, esophageal, liver, colon, pancreatic, and gastrointestinal. However, the specific gut microbial strains associated with the development or progression of cancers in various tissues remain largely unclear. Here, we summarize current research findings on the gut microbiome of multiple cancers. This review aims to identify key gut microbial targets that closely influence cancer development based on current research findings. To accurately evaluate the effectiveness of the gut microbiome as a clinical tool for cancer, further research is needed to explore its potential as a biomarker and therapeutic strategy.